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- W2354980939 abstract "Objective:To investigate the pathogenesis of HBV related glomerulonephritis(HBVGN), the deposition of HBV related antigens in glomeruli were examined, and the association between antigen deposition and state of HBV infection as well as the clinicopathoplocial manifestations were investigated. And in this study, the active replications of HBV in kidney were also examined. Methodology:42 renal patients with HBV infection were involved in this study, including 30 patients whose renal biopsy revealed membranous changes and 12 membranoproliferative changes. Glomerular depositions of HBsAg, HBcAg and HBeAg were detected with immunohistochemistry. PCR and nested PCR were applied in the detection of HBV DNA and cccDNA in isolated glomeruli microscopically dissected from renal biopsy slides, and in the detection of HBV DNA and cccDNA in circulation(including serum and peripheral blood mononuclear cells). The association between clinical manifestations and pathological changes were investigated retrospectively. Results:HBV antigens were detected positive in glomeruli in 83.3% of the patients with membranous changes, and in 33% of the patients with membranous proliferative changes (83.3% vs 33%, P=0.007). In patients with membranous changes, the prodominant pattern of antigens deposition in glomeruli was HBcAg and HBeAg. A significant correlation was found between HBeAg deposition in glomeruli and positivity of HBeAg antigen in serum(P=0.015). Glomerular antigen deposition was more frequently found in patients with elevated serum transaminase. HBV DNA and cccDNA in glomeruli was more frequently found in patients with active HBV infection. Positivity of HBV DNA and cccDNA detection in glomeruli was consistent with the positivity of HBV DNA and cccDNA detection in circulation in most of the patients. Conclusion:The positive rate of HBV antigens in glomeruli in patients with membranous changes was significantly higher than in patients with membranous proliferative changes. HBeAg and HBcAg are main antigens deposited in glomeruli of HBVGN. Significant correlation was found between glomerular HBeAg deposition and HBeAg seropositivity. HBV antigens deposition in gloemruli was more frequently found in patients with liver dysfunction. Consistent findings of cccDNA in glomeruli and circulation make it hard to rule out the influence of circulating cells to the detection of cccDNA in glomeruli." @default.
- W2354980939 created "2016-06-24" @default.
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- W2354980939 date "2004-01-01" @default.
- W2354980939 modified "2023-09-23" @default.
- W2354980939 title "Detection of HBV antigens and cccDNA in glomeruli of patients with HBV infection and renal disease" @default.
- W2354980939 hasPublicationYear "2004" @default.
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