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- W2355006579 abstract "OBJECTIVE:To develop a simple,sensitive and rapid RP-HPLC with ultraviolet detector method for the deˉtermination of clozapine in human plasma.METHODS:The plasma samples(1ml)were extracted with5ml ether after alkaˉlization with0.5mol/ml NaOH(50μl).The organic phase was back-extracted with100μl of0.1mol/ml KH 2 PO 4 (adjusted pH to2.2with H 3 PO 4 ).The separation column was Dikma Diamonsil C 18 column and the protection column was Waters Nova-Pak C 18 column.The mobile phase consisted of0.5%triethylamine-acetonitrile(74∶26,v/v)with flow rate of1ml/min.The deˉtecting wavelength was215nm.RESULTS:A linearity was obtained in the range of100～2000ng/ml(r=0.999),the lowest detectable concentration in plasma was50ng/ml.The extraction recovery was between80.3%and84.8%.The relative stanˉdard deviations of intra-day and inter-day assay were within3.5%～8.3%.CONCLUSION:The established method was shown to be sensitive,accurate and simple for the determination of clozapine levels in human plasma.It was suitable for the pharmacokinetic and TDM study of clozapine." @default.
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- W2355006579 date "2003-01-01" @default.
- W2355006579 modified "2023-09-26" @default.
- W2355006579 title "Determination of the Levels of Clozapine in Human Plasma by RP-HPLC" @default.
- W2355006579 hasPublicationYear "2003" @default.
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