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- W2355017890 abstract "Objective To investigate the influence of ginkgo biloba extract(GBE) on serum e-selectin and vascular cell adhesion molecules-1(VCAM-1) of patient swith chronic obstructive pulmonary disease(COPD) in acute exacer-bation.Methods Sixty patients with COPD at acute exacerbation stage were randomly divided into two groups: con-ventional treatment(CT) group and GBE treatment(GBE) group,with 30 cases in each group,and 30 healthy adults served as the controls.All COPD patients were given conventional treatment,while for the patients in GBE group,20 ml GBE were given through intravenous drip everyday in addition for 2 weeks.The levels of the serum E-selectin and VCAM-1 in the blood samples were determined with enzyme linked immunosorbent assay(ELISA),and the pul-monary function of both groups were measured before and after the treatment.Results The level of E-selectin and VCAM-1 were significantly higher in COPD patients with acute exacerbation compared to the control group before treatmen(t 0.01).After intervention,the level of E-selectin and VCAM-1 in both treatment groups were signifi-cantly decreased(all 0.05),and the decrease in GBE group was more prominen(t 0.05).After treatment,The level of FEV1% and FEV1/FVC in GBE group increased( 0.05),and those in the CT group were not signifi-cantly different( 0.05).Conclusions GBE may obviously decrease the serum level of E-selectin and VCAM-1 and improve the pulmonary function in patients with COPD at acute exacerbation stage." @default.
- W2355017890 created "2016-06-24" @default.
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- W2355017890 date "2011-01-01" @default.
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- W2355017890 title "Changes and clinical significance of serum cell adhesion molecules among patients with chronic obstructive pulmonary disease" @default.
- W2355017890 hasPublicationYear "2011" @default.
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