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- W2355025356 abstract "To investigate the effects of tert-butylhydroquinone( tBHQ) on heat stress-induced oxidative damage in liver of mice,fifty six-w eek-old ICR male mice w ere divided into 2 groups w ith 25 mice in each group.tBHQ(-) group received a basal diet,and tBHQ( +) group received the basal diet supplemented w ith 1%tBHQ. After 14 days of feeding,mice w ere exposed to the elevated ambient temperature( 42 ℃) daily for 2 h.During the period of 8 consecutive days,five mice in each group w ere sacrificed to collect liver before heat stress( 0 day after heat stress) and at 1,2,4 and 8 days after heat stress,respectively. Liver w eight and antioxidative indices w ere determined,transcription factor E2 related factor 2( Nrf2) and heme oxygenase-1( HO-1) protein expressions in liver were determined by immunohistochemical detection,and the expressions of Nrf2 gene and Nrf2-regulated genes w ere analyzed by real time-PCR detection. The results show ed as follow s: 1) liver index of tBHQ(-) group recovered to normal level at 4 days after heat stress,w hile that of tBHQ( +) group recovered to normal level at 2 days after heat stress. 2) Compared w ith tBHQ(-) group,total superoxide dismutase( T-SOD) activity of tBHQ( +) group w as significantly increased at 0 day after heat stress( P 0. 05),and reduced glutathione hormone( GSH) content and the activities of T-SOD,copper,zinc-superoxide dismutase( Cu,Zn-SOD),glutathione peroxidase( GSH-Px) and catalase( CAT) of tBHQ( +) group were significantly reduced at 4 days after heat stress( P0.05). 3) At 2 days after heat stress,liver injury of tBHQ(-) group w as more serious than that of tBHQ( +) group. 4) Nrf2 protein expression w as not detected in liver at 0 day after heat stress,but it w as detected at all the time points after heat stress of tBHQ(-) group and was detected at all the time points of tBHQ( +) group; HO-1 protein expression was detected in liver at 0,1,4 and 8 days after heat stress of tBHQ(-) group,and at 0,1 and 2 days after heat stress of tBHQ( +) group. 5) Compared w ith tBHQ(-) group,multiple genes of kelch-like ECH-associated protein 1( Keap1)-Nrf2/ARE signing pathway of tBHQ( +) group were significantly increased( P0.05). In conclusion,dietary supplementation of 1% tBHQ can alleviate heat stress-induced oxidative damage in liver of mice." @default.
- W2355025356 created "2016-06-24" @default.
- W2355025356 creator A5091217057 @default.
- W2355025356 date "2014-01-01" @default.
- W2355025356 modified "2023-09-23" @default.
- W2355025356 title "Tert-Butylhydroquinone: Preventive Effects on Heat Stress-Induced Oxidative Damage in Liver of Mice" @default.
- W2355025356 hasPublicationYear "2014" @default.
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