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- W2355029790 abstract "OBJECTIVE To investigate the pharmacokinetics of piroxicam patches after continuous transdermal administration in Chinese healthy volunteers.METHODS 11 volunteers were administrated topically with piroxicam patches 48 mg every two days for 14 days,the drug concentrations of plasma sample from the 11 volunteers were determined by HPLC.The pharmacokinetic parameters were calculated by DAS 1.0software.RESULTS The concentration of piroxicam in plasma has reached steady-state on tenth day.The main pharmacokinetic parameters tmax,t1/2and Cmaxwere(43.8±15.5)h,(62.3± 23.7)h and(40.6±11.3)μg·L-1,respectively;AUC0-τand AUC0-∞ were(4 177.3±1 376.0)and(5 867.9±2 768.7)μg· L-1·h,respectively;The degree of fluctuation(DF)was 1.09±0.24.There was no significant difference in Ka,t1/2 Ka,MAT,Ke,CL/F,V/F,t1/2,Cmax,AUC0-tand AUC0-∞between the single-dose and the multi-dose study(P0.05).CONCLUSION There was no accumulation in human body after taking 48 mg piroxicam patches every two days for 14 days and no volunteer had any adverse reaction." @default.
- W2355029790 created "2016-06-24" @default.
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- W2355029790 date "2010-01-01" @default.
- W2355029790 modified "2023-09-26" @default.
- W2355029790 title "Pharmacokinetics of imported piroxicam patches after continuous transdermal administration in Chinese healthy volunteers" @default.
- W2355029790 hasPublicationYear "2010" @default.
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