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- W2355079442 abstract "【Objecive】 To investigate the platelet 5-HT level in chronic obstructive pulmonary disease(COPD) patients.【Methods】 51 COPD patients and 49 health controls were collected.The pulmonary function test including FEV1,FVC and FEV1/FVC% were performed in COPD patients.Pulmonary systolic arterial pressure(PASP) was measured by three-dimensional color Doppler ultrasonography.And platelet 5-HT levels in COPD and control group were assayed by high performance liquid chromatography(HPLC).【Results】 In COPD group,no matter acute exacerbation phase or stable phase,platelet 5-HT levels were significant lower than control group(P 0.01).But there was no relationship between platelet 5-HT levels and severity of COPD(Ⅱ,Ⅲ,Ⅳ) in patients.Compared with COPD without pulmonary arterial hypertension(PAH) patients,platelet 5-HT levels were reduced in COPD with PAH patients(P 0.05),and 5-HT levels were lower in COPD with severity PAH patients than with mild PAH patients,although there was no statistics difference.There was a negative correlation between platelet 5-HT level and PASP(r =-0.368).【Conclusions】 In COPD group,especially COPD with PAH,platelet 5-HT level was significantly decreased,and 5-HT level has correlation with PAH.5-HT as an important vasoactive substance may play important roles in the development of COPD,especially promote PAH in advanced stage of COPD,which maybe an index to evaluation the risk of COPD with PAH and the severity of PAH." @default.
- W2355079442 created "2016-06-24" @default.
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- W2355079442 date "2011-01-01" @default.
- W2355079442 modified "2023-09-27" @default.
- W2355079442 title "Change of platelet 5-HT level in chronic obstructive pulmonary disease patients" @default.
- W2355079442 hasPublicationYear "2011" @default.
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