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- W2355101102 abstract "Objective To investigate the role of HCMV infection in the development of colorectal cancer and its possible mechanisms.Methods Tumor tissue samples were collected from 50 patients with colorectal cancer and samples of normal tissue 10 cm distant from surgical margins were collected to serve as controls.HCMV infection was detected by RT-PCR in tumor tissue and tumor-adjacent normal tissue,while the expression of Bcl-2 was evaluated with immunohistochemical straining.Results The rate of positivity for HCMV IE2 was 40%(20/50) in tumor tissue and 6%(3/50) in adjacent normal tissue;the difference in the two was statistically significant(P0.05).The rate of positivity for Bcl-2 was 36%(18/50) in tumor tissue and 8%(4/50) in adjacent normal tissue;the difference between the two was statistically significant(P0.05).Positivity for Bcl-2 was higher in the 50 samples of HCMV-positive tumor tissue than in the HCMV-negative tumor tissue,and the level of Bcl-2 in tumor tissue correlated with HCMV infection(χ2=5.834,P0.05).Conclusion HCMV infection is related to the development of colorectal cancer and a possible mechanism may be its effect on the expression of Bcl-2." @default.
- W2355101102 created "2016-06-24" @default.
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- W2355101102 date "2011-01-01" @default.
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- W2355101102 title "Correlation between human cytomegalovirus infection and expression of the Bcl-2 gene in colorectal cancer" @default.
- W2355101102 hasPublicationYear "2011" @default.
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