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- W2355133061 abstract "Food was removed for 2 days,then the rats were refeeded for 3 days.Sixty days later,rats were detected the ability of spatial learning and memory by Morris water maze.Phosphorylation levels and distributions of tau protein and neurofilament(NF),level and distribution of protein phosphatase 2A catalytic subunit were detected with specific antibodies by Western blotting.Model rats showed significantly longer latency to find the hidden platform in Morris water maze than the control rats(P 0.05).The phosphorylation levels of tau was elevated,and the level of PP-2A cytalytic subunit was significantly decreased(P 0.05).Starvation leads to impairment of spatial learning and memory in rats,hyperphosphorylation of tau protein,and the down-regulation of PP-2A may be at least one of the underlying mechanisms." @default.
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- W2355133061 date "2010-01-01" @default.
- W2355133061 modified "2023-09-25" @default.
- W2355133061 title "Impact of Repeated Starvation on Neuronal Cytoskeleton Protein Phosphorylation and Spatial Learning and Memory in Rats" @default.
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