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- W2355141134 abstract "Objective To evaluate the value of pituitary down-regulation induced by gonadotrophin releasing hormone agonist ( GnRH-a) in the outcome of in vitro fertilization-embryo transfer ( IVF-ET) . Methods Totally 185 cases,which involved 187 cycles undergoing IVF/intracytoplasmic sperm injection ( ICSI) treatment,admitted in our reproductive medicine center from Jan. to Dec. 2008 were retrospectively analyzed. All patients got triptorelin 0. 05 mg per day from mid-luteal phase of the prior menstrual cycle ( day18 to 21) . According to the level of pituitary down-regulation before controlling ovarian hyperstimulation ( COH) ,patients were divided into 2 groups: full-down-regulation group ( group A,95 cycles) and not full-down-regulation group ( group B,92 cycles) . Their age,doses of GnRH-a and gonadotropine ( Gn) ,number of retrieved oocytes and metaphase Ⅱ oocytes,fertilization rate,high quality embryos and clinic pregnancy rate were compared. Results The rate of clinic pregnancy in the group A was obviously higher than that in group B ( 48. 94% vs 32. 61% ,P 0. 05) . No difference was observed in the abortion rate. Although no difference observed among the doses of GnRH-a and Gn,number of retrieved oocytes and metaphase Ⅱ oocytes and fertilization rate in 2 groups,the high quality embryos in group A was significantly higher than group B ( 43. 70% vs 31. 80% , P 0. 05) . Conclusion Complete and proper pituitary down-regulation induced by GnRH-a in long protocol exerts great influence on the outcome of IVF treatment. The standard used in our reproductive center could be a good choice during the pituitary down-regulation." @default.
- W2355141134 created "2016-06-24" @default.
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- W2355141134 date "2009-01-01" @default.
- W2355141134 modified "2023-09-27" @default.
- W2355141134 title "Value of proper pituitary down-regulation in treatment of IVF-ET" @default.
- W2355141134 hasPublicationYear "2009" @default.
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