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- W2355143784 abstract "Objective To observe the efficacy and safety of three different doses of palonosetron on the incidence and severity of postoperative nausea and vomiting(PONV) for gynecological surgery. Methods sixty patients(ASAⅠ-Ⅱ)undergoing gynecological surgery with general anesthesia,scheduled for intravenous analgesia were divided into three groups randomly: Group A(palonosetron 0.075 mg,n=20),Group B(palonosetron 0.15 mg,n=20) and Group C(palonosetron 0.25 mg,n=20).A single IV dose of palonosetron(0.075 mg,0.15 mg,or 0.25 mg)was administered immediately before induction of anesthesia.Complete response(CR: no emetic episodes and no rescue medication),nausea severity and TTF(time to treatment failure) were observed during the 0 to 24 h,24 to 72 h,0 to 6 h,6 to 72 h and 0 to 72 h postoperative time intervals. Results ①CR rates were similar for the 0 to24 h(p=0.194),0 to 6h(p=0.912),0 to 72h(p=0.252) postoperative interval for three groups.Compared with Group A,CR rates for Group B and Group C were significantly increased for the 24 to 72 h(p=0.025),6 to 72 h interval(p=0.016).②Compared with Group A,Group B and Group C associated with a significant downward shift toward less intense nausea for the 24 to 72 h(p=0.025),6 to 72 h interval(p=0.018).③The proportion of treatment failure for Group B(15%)and Group C(15%) is significantly decreased for the 0 to 24 h interval(p=0.043)④CR rates,nausea seversity and proportion of treatment failure were similar in both of Group B and Group C for every interval. Conclusion A single IV dose of palonosetron 0.15mg before gynecological surgery significantly increased the CR rate(no emetic episodes and no rescue medication) and decreased nausea severity from 24 to 72 h.It also decreased the proportion of treatment failure for 0~24 h.Efficacy of palonosetron was not significantly increased with increasing doses to 0.25 mg." @default.
- W2355143784 created "2016-06-24" @default.
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- W2355143784 date "2011-01-01" @default.
- W2355143784 modified "2023-09-24" @default.
- W2355143784 title "OBSERVATION OF DIFFERENT DOSES OF PALONOSETRON ON THE PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING(PONV) FOR GYNECOLOGICAL SURGERY" @default.
- W2355143784 hasPublicationYear "2011" @default.
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