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- W2355145957 abstract "OBJECTIVE To investigate the effect of ventilation on the changes in TNF-α concentration of BALF on acute lung injury model.METHODS Forty healthy male Sprague-Dawley rats were randomly divided into five groups LV,HV,LV2P,LV5P,LV8P and the rat model of acute lung injury was built.Mechanical ventilation was employed in the test groups.Rats were sacrificed after 2 hours ventilation when the serum acquired.The supernatant of BALF was detected for TNF-α concentration.RESULTS The changes in TNF-α content of serum:the TNF-α contentration of serum was higher in HV group than that in LV group(P0.01).It was higher in LV2P group than that in LV5P and LV8P groups(P0.01).The changes in TNF-α content of BALF: The TNF-α content of BALF was higher in HV group than that in LV group(P0.01).It was higher in LV8P group than that in LV2P and LV5P groups(P0.01).CONCLUSIONS The low tidal volume and with PEEP ventilation have protective effects." @default.
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- W2355145957 date "2009-01-01" @default.
- W2355145957 modified "2023-09-24" @default.
- W2355145957 title "Effects of Ventilation on TNF-α Expression in a Rat Model of Acute Lung Injury" @default.
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