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- W2355153000 abstract "Objective To observe effects of erythropoietin(EPO) on marrow progenitor cells and the hematological system in chronic kidney failure(CRF) patients and to investigate mechanism of EPO-based therapy.Methods Subcutaneous injection of EPO(3000-6000 U,thrice per week) were given in 20 CRF patients.Draw marrow from posterosuperior iliac spine before therapy and 12 weeks after treatment.The changes in marrow progenitor cells and complete blood count were observed.Results After the treatment,hemoglobin,hematocrit,white blood cells and platelets increased creatinine in serum decreased;and there were significant differences(P0.01).CFU-E,CFU-GM and CFU-F increased significantly after treatment(P0.01).The settlement yield of CFU-F is olirect correlation with the settlement yield of CFU-E and CFU-GM(r=0.32,r=0.49,P0.05).Conclusion Intradermal injection of EPO reestablishes the marrow hematopoietic microenvironment,protects hematopoietic stem cell to ecesis,restores self-replication and promotes differentiation." @default.
- W2355153000 created "2016-06-24" @default.
- W2355153000 creator A5004706997 @default.
- W2355153000 date "2012-01-01" @default.
- W2355153000 modified "2023-09-27" @default.
- W2355153000 title "Erythropoietin Influences Marrow Progenitor Cells in Chronic Kidney Failure(CRF) Patients" @default.
- W2355153000 hasPublicationYear "2012" @default.
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