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- W2355161938 abstract "Objective: To study the effect of Xiongshao Capsule(XSC) on nuclear transcription factor κB(NF-κB) and inl ammation related factors of rabits with athrosclerosis(AS) and to investigate the new target for inhibiting the inflammatory response. Methods: Sixty New Zealand rabbits were randomly divided into control group, model group, low-dose XSC group, middle-dose XSC group, large-dose XSC group and simvastatin group. The rabbits of AS were established by simple high-fat feeding method. The levels of interleukin-2(IL-2), interleukin-6(IL-6) and the tumor necrosis factors-α(TNF-α) in the serum were tested by blood tests after remodeling, before delivery of drugs, after 6, 12, 15 weeks of delivery, separately. The activity expression of NF-κB p65 in thoracic aortas was tested by electrophoretic mobility shift assay(EMSA), and NF-κB mRNA was tested by Real-time quantitative PCR. Results: The serum inflammatory factors in medicated groups were increased to dif erent levels after 15 weeks. The IL-2 in middle-dose XSC group, high-dose XSC and simvastatin groups were lower than that in model group(P0.01, P0.05), and TNF-α were signii cantly lower(P0.05). The binding activity of NF-κB in simvastatin group was lower than that in model group(P0.05). Conclusion: The XSC can lower the binding activity of NF-κB p65 in aortas of rabbits with AS and reduce the serum inl ammation related factors, which could prevent AS through anti-inflammatory response." @default.
- W2355161938 created "2016-06-24" @default.
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- W2355161938 date "2014-01-01" @default.
- W2355161938 modified "2023-09-24" @default.
- W2355161938 title "Effect of Xiongshao Capsule on NF-κB and inflammation related factors in aortas of rabbits with atherosclerosis" @default.
- W2355161938 hasPublicationYear "2014" @default.
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