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- W2355163952 abstract "Objective:To study clinical pathological significance of P-gp expression in non-small cell lung cancer and examine the impact of the P-glycoprotein expression level in non-small cell lung cancer tumor-associated fibroblast to the early recurrence of postoperative patients.Methods:P-gp of lung cancer tissue and normal lung tissue were detected by using Max-Vision TMimmunohistochemical method,to observe the p-gp expression level in TAF of NSCLC lung cancer tissue and normal lung tissue,and followed up the patient,to find the relation between the expression level with the recurrence or distant metastasis of postoperative patients.Results:The positive rate of P-gp expression in TAF of 48 NSCLC patients was 70.8%,higher than the normal lung tissue(P0.01).There was a siganificant difference between age,degree of tumor differentiation,clinical stage,with or without lymph node metastasis(P0.05).And there was no obvious relationship with sex,tumor size and types of histology(P0.05).The postoperative patients with p-gp strongly positive expression hade higher rate of recurrence or distant metastasis than the negative or weakly positive of NSCLC within one year.Conclusion:P-gp promotes the formation of tumor drug resistance.The expression level of P-gp in the TAF of NSCLC patient was associated to early recurrence and distant metastasis of postoperative patients." @default.
- W2355163952 created "2016-06-24" @default.
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- W2355163952 date "2012-01-01" @default.
- W2355163952 modified "2023-09-26" @default.
- W2355163952 title "P-glycoprotein expression in non-small cell lung cancer(NSCLC)and its significance" @default.
- W2355163952 hasPublicationYear "2012" @default.
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