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- W2355172396 abstract "Objective To investigate the long-term efficacy of lamivudine(LAM)and adefovir(ADV) combination therapy in chronic hepatitis B related advanced fibrosis and/or compensated cirrhosis.Methods Two hundred and eight eligible Chinese patients were randomly assigned in a 1:1 ratio to receive either LAM or ADV for the first 24 weeks. According to virologic response at 24 weeks,the patients were defined as complete response(CR)(HBV DNA60 IU/mL), partial response(HBV DNA 60-2 000 IU/mL)(PR),inadequate response(IR)(HBV DNA2 000 IU/mL) and the occurrence of virological breakthrough(HBV DNA greater than the minimum value of 1 lg).The patients with CR and PR continued monotherapy for 48 weeks while the patients with IR or virological breakthrough switched to combined therapy (ADV was added into LAM initial group,and ADV initial group).The primary endpoint was the CR in the 48~(th) week;the secondary endpoint was the clinical outcome in the 48~(th) week.Results 56.73%in LAM and 35.57%in ADV group achieved CR 24 weeks post treatment.The proportion of PS in LAM and ADV group were 21.15%and 28.84%in the 24~(th) week, 22.11%in LAM group and 35.57%in ADV group were IR at 24 weeks and 39 cases of those switching to combination therapy(initial LAM 15 cases add ADV on and initial ADV 24 cases add LAM on) and 21 cases(LAM:8 and ADV:13 ) continued monotherapy to 48 weeks.The patients who gained CR in the 24~(th) week achieved more CVS than those gained PS and IR in the 24~(th) week(P0.01).Biochemical response and serum liver fibrosis marks also improved significantly after treatment.Conclusion Initial LAM or ADV monotherapy and then add-on combined therapy in chronic hepatitis B patients with liver cirrhosis can achieve rapid and sustained inhibition of viral replication,improving liver biochemistry and fibrosis. Early virological response in LAM or ADV therapy in the 24~(th) weeks were of great value for virological response prediction in the 48~(th) weeks." @default.
- W2355172396 created "2016-06-24" @default.
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- W2355172396 date "2012-01-01" @default.
- W2355172396 modified "2023-09-25" @default.
- W2355172396 title "One year evaluation of virological response and clinical outcome of lamivudine and adefovir dipivoxil optimized therapy in chronic hepatitis B-related fibrosis and/or compensated cirrhosis" @default.
- W2355172396 hasPublicationYear "2012" @default.
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