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- W2355172778 abstract "AIM:Research on the tetrastigma hemsleyanum diels et gilg flavone(sanyeqing),which influences the tumor volume and the expression level of TGFβ1,PGE2,COX-2of LLC tumor bearing C57BL/6 mice,to explore the possible mechanism of reverse tumor immune escape function of radix tetrastigme to tumor-bearing mice.METHODS:LLC tumor bearing C57BL/6mice models were established by tumor homogenate inoculation method and were randomly divided into normal group,model control group,high dose group of the total flavonoids from radix tetrastigmae,middle dose group of the total flavones from radix tetrastigmae,low dose group of the total flavonoids from radix tetrastigmae.Stripped the tumor tissue and weighed after 14 days continuous administration.The ELISA method was used to detected the TGFβ1,PGE2and COX-2content in serum.RESULTS:Tumor volume:compared with the model control group,high-dose group,middledose group had significant difference in tumor volume(P0.05).Tumors size in the order:model control grouplow-dose groupmiddledose group high-dose group.TGF-β1,PGE2 and COX-2content in serum:after the experiment,the experimental groups were significantly higher than the normal group(P0.01),within groups,high-dose group low-dose group(P 0.05).CONCLUSION:The tetrastigma hemsleyanum diels et gilg flavone highdose group had a better effect in suppressing tumor growth,the middle dose group didn't play an effective role,And the low-dose group had the most weak effect in suppressing tumor growth.The tumor suppression effect of tetrastigma hemsleyanum diels et gilg flavone may be related to the lower levels of TGF-β1expression in peripheral blood,and may decrease the level of PGE2,COX-2expression,so as to achieve reverse tumor escape,to achieve the antitumor effect." @default.
- W2355172778 created "2016-06-24" @default.
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- W2355172778 date "2014-01-01" @default.
- W2355172778 modified "2023-09-26" @default.
- W2355172778 title "Effect of tetrastigma hemsleyanum diels et gilg flavone on the immunosuppressive associated cytokines in Lewis lung cancer mice" @default.
- W2355172778 hasPublicationYear "2014" @default.
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