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- W2355172823 abstract "Objective To investigate the clinical efficacy of enalapril and irbesartan,singly or combined,for aorta remodeling and relevant mechanisms. Methods Twenty-four renovascular hypertensive rats (RHR)developed by two-kidney and one-clip method were treated consecutively with normal saline(model group,n=6),enalapril [10 mg/(kg ·d),n=6],irbesartan [50 mg/(kg ·d),n=6] and enalapril+irbesartan [5 mg/(kg ·d)+25 mg/(kg ·d),n=6] for 6 weeks. Six sham-operated rats were used as controls. Aortic morphology and structural changes in the media were observed by HE staining,immunohistochemical staining and Masson staining. The content of angiotensin Ⅱ(Ang Ⅱ) was measured by radioimmunoassay. The activities and mRNA levels of Na+pump and Ca2+ pump in aortic media were determined by enzyme colorimetry and real-time PCR respectively. Results In the model group,the media area of aorta and the Ang Ⅱ content were significantly increased while the activities and mRNA levels of Na+pump and Ca2+ pump in aortic media obviously decreased. In the enalapril group and irbesartan group,Na+pump and Ca2+ pump activities were increased,with Ang Ⅱ content obviously decreased in enalapril group but increased in irbesartan group(P0.01). The mRNA levels of sodium pump α1-subunit and plasma membrane calcium pump isoform 1 in aorta smooth muscle tissue were significantly increased in enalapril group (P0.01). The amelioration of blood pressure,Na+ pump and Ca2+ pump activities,media area and thickness in combination group were significantly greater than that in single-drug intervened group (P0.01). Conclusion The amelioration of aorta remodeling induced by the combination of enalapril and irbesartan therapies may be associated with the increase of Na+pump and Ca2+ pump activities. There may be some synergistic effects on the amelioration of Na+ pump and Ca2+ pump activities and aorta remodeling from combination of the two drugs. Enalapril exerts its activating effects on inhibited Na+ pump and Ca2+ pump activities probably by increasing their mRNA expressions." @default.
- W2355172823 created "2016-06-24" @default.
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- W2355172823 date "2010-01-01" @default.
- W2355172823 modified "2023-09-26" @default.
- W2355172823 title "Effects of Enalapril and Irbesartan Given Singly or Combined on Aorta Remodeling and Na~+ Pump and Ca~(2+) Pump in Renovascular Hypertensive Rats" @default.
- W2355172823 hasPublicationYear "2010" @default.
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