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- W2355175903 abstract "Objective To explore the correlation of expression of cell adhesion molecules(SICAM-1,CD11b,CD62P,CD63) in Type 2 diabetes patients with nephrotic microangiopathy and urine albuminuria.Methods The expression of CD11b,CD62P and CD63 were determined by flow cytometry(FCW),SICAM-1 was determined by ELISA,Urine albuminuria was determined by RIA,95 patients(including 65 patients with nephrotic microangiopathy),and 35 healthy people were determined.Results The levels of expression of cell adhesion molecules in all type 2 diabetes patients were significantly higher than that in healthy controls(P0.05-0.01);the expression of cell adhesion molecules in microalbuminuria and clinical albuminuria patients were significantly higher than that in normal albuminuria patients without nephrotic microangiopathy(P0.05-0.01),the expression of the four molecular markers was increased along with the progress of the disease.the expression of SICAM-1,CD11b,CD62P and CD63 were all correlated with urine alumin excretion(UAER)(P0.05).Conclusion The enhanced expression of CAMs in type 2 diabetes patients aree closely associated with the nephrotic microangiopathy and correlated with severrity degree of DN,combined UAER to detect was useful for diagnosis and monitoring the clinical course of DN,avoiding nephrotic microangiopathy." @default.
- W2355175903 created "2016-06-24" @default.
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- W2355175903 date "2008-01-01" @default.
- W2355175903 modified "2023-09-23" @default.
- W2355175903 title "Expression of cell adhesion molecules in type 2 diabetes patients with nephrotic microangiopathy" @default.
- W2355175903 hasPublicationYear "2008" @default.
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