Matches in SemOpenAlex for { <https://semopenalex.org/work/W2355200265> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2355200265 endingPage "474" @default.
- W2355200265 startingPage "471" @default.
- W2355200265 abstract "Objective Mouse factor Ⅶ（mfⅦ）, ligand of tissue factor （TF）which is frequently overexpressed during neovascularlzation activated bv tumor growth, was fused to staphylococcus enterotoxin A （SEA） that mediates greater intensity of T-cell activation against tumor cells. The anti-tumor effects of the mfⅦ-SEA chimeric protein were evaluated. Methods Fusion of SEA and mfⅦ cDNA was constructed using adenovirus vector and produced in 293 packaging cell lines. The 293 cells containing the adenovirus were administered subcutaneously to mice. Fluorescence studies at the injection site and the liver were performed 3 days later. Mouse prostatic tumor RM-1 cells and mouse sarcoma MCA 205 H12 cell lines were then used in mice to create lung metastasis and subcutaneous tumor to carry out efficacy evaluation, respectively. Results Adenovirus released from the injected 293 cells only infected the subcutaneous tissue at the injection site. The in vivo experiments in mice revealed that formation of lung metastasis was strongly inhibited by the mfⅦ-SEA （23 ±8 ） compared to the vacant vector control group（ 193±38） and PBS control group（211±42） （ P 〈 0.01 ）. The mfⅦ-SEA also strongly suppressed tumor growth at the subcutaneous injection site （342.6 ±107.1 ） mm^3 compared to that of vacant vector control （2244.3±350） mm^3 and SEA （1208.3±210） mm^3 by the 23rd day. Conclusion The chimeric protein mfⅦ-SEA significantly inhibits lung metastasis formation and local tumor growth.Key words: Factor Ⅶ; Staphylococcus enterotoxin A; Neoplasm growth; Neoplasm metastasis" @default.
- W2355200265 created "2016-06-24" @default.
- W2355200265 creator A5029389146 @default.
- W2355200265 creator A5029636776 @default.
- W2355200265 creator A5066662004 @default.
- W2355200265 creator A5081844561 @default.
- W2355200265 creator A5087288694 @default.
- W2355200265 date "2005-08-01" @default.
- W2355200265 modified "2023-09-25" @default.
- W2355200265 title "Anti-tumor effects of mouse factor VII-staphylococcus enterotoxin A (mfVII) chimeric protein in mice" @default.
- W2355200265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16188143" @default.
- W2355200265 hasPublicationYear "2005" @default.
- W2355200265 type Work @default.
- W2355200265 sameAs 2355200265 @default.
- W2355200265 citedByCount "2" @default.
- W2355200265 crossrefType "journal-article" @default.
- W2355200265 hasAuthorship W2355200265A5029389146 @default.
- W2355200265 hasAuthorship W2355200265A5029636776 @default.
- W2355200265 hasAuthorship W2355200265A5066662004 @default.
- W2355200265 hasAuthorship W2355200265A5081844561 @default.
- W2355200265 hasAuthorship W2355200265A5087288694 @default.
- W2355200265 hasConcept C104317684 @default.
- W2355200265 hasConcept C121608353 @default.
- W2355200265 hasConcept C123894998 @default.
- W2355200265 hasConcept C126322002 @default.
- W2355200265 hasConcept C150903083 @default.
- W2355200265 hasConcept C153911025 @default.
- W2355200265 hasConcept C185592680 @default.
- W2355200265 hasConcept C207001950 @default.
- W2355200265 hasConcept C2776390293 @default.
- W2355200265 hasConcept C2777714996 @default.
- W2355200265 hasConcept C2779013556 @default.
- W2355200265 hasConcept C40767141 @default.
- W2355200265 hasConcept C502942594 @default.
- W2355200265 hasConcept C547475151 @default.
- W2355200265 hasConcept C55493867 @default.
- W2355200265 hasConcept C66999527 @default.
- W2355200265 hasConcept C71924100 @default.
- W2355200265 hasConcept C86803240 @default.
- W2355200265 hasConceptScore W2355200265C104317684 @default.
- W2355200265 hasConceptScore W2355200265C121608353 @default.
- W2355200265 hasConceptScore W2355200265C123894998 @default.
- W2355200265 hasConceptScore W2355200265C126322002 @default.
- W2355200265 hasConceptScore W2355200265C150903083 @default.
- W2355200265 hasConceptScore W2355200265C153911025 @default.
- W2355200265 hasConceptScore W2355200265C185592680 @default.
- W2355200265 hasConceptScore W2355200265C207001950 @default.
- W2355200265 hasConceptScore W2355200265C2776390293 @default.
- W2355200265 hasConceptScore W2355200265C2777714996 @default.
- W2355200265 hasConceptScore W2355200265C2779013556 @default.
- W2355200265 hasConceptScore W2355200265C40767141 @default.
- W2355200265 hasConceptScore W2355200265C502942594 @default.
- W2355200265 hasConceptScore W2355200265C547475151 @default.
- W2355200265 hasConceptScore W2355200265C55493867 @default.
- W2355200265 hasConceptScore W2355200265C66999527 @default.
- W2355200265 hasConceptScore W2355200265C71924100 @default.
- W2355200265 hasConceptScore W2355200265C86803240 @default.
- W2355200265 hasIssue "8" @default.
- W2355200265 hasLocation W23552002651 @default.
- W2355200265 hasLocation W23552002652 @default.
- W2355200265 hasOpenAccess W2355200265 @default.
- W2355200265 hasPrimaryLocation W23552002651 @default.
- W2355200265 hasRelatedWork W1480060255 @default.
- W2355200265 hasRelatedWork W1514089406 @default.
- W2355200265 hasRelatedWork W1526488374 @default.
- W2355200265 hasRelatedWork W1641348134 @default.
- W2355200265 hasRelatedWork W1965134167 @default.
- W2355200265 hasRelatedWork W1967157559 @default.
- W2355200265 hasRelatedWork W1970616130 @default.
- W2355200265 hasRelatedWork W2017836437 @default.
- W2355200265 hasRelatedWork W2033437777 @default.
- W2355200265 hasRelatedWork W2039768028 @default.
- W2355200265 hasRelatedWork W2051625373 @default.
- W2355200265 hasRelatedWork W2067385043 @default.
- W2355200265 hasRelatedWork W2074593982 @default.
- W2355200265 hasRelatedWork W2088094615 @default.
- W2355200265 hasRelatedWork W2107008660 @default.
- W2355200265 hasRelatedWork W2301089782 @default.
- W2355200265 hasRelatedWork W2360431151 @default.
- W2355200265 hasRelatedWork W2413920225 @default.
- W2355200265 hasRelatedWork W2416050007 @default.
- W2355200265 hasRelatedWork W2461002762 @default.
- W2355200265 hasVolume "27" @default.
- W2355200265 isParatext "false" @default.
- W2355200265 isRetracted "false" @default.
- W2355200265 magId "2355200265" @default.
- W2355200265 workType "article" @default.