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- W2355223874 abstract "Objective To develop a method for the determination of vancomycin and norvancomycin concentration in human serum by high-performance liquid chromatography (HPLC).Methods The chromatographic bar was Hypersil BDS C18 (4.6 mm×250 mm,5 μm). The mobile phase was tribasic potassium phosphate buffer-methanol (87∶13) and the flow rate was 1 ml·min-1. The detecting wavelength of ultraviolet was 236 nm. Arilin was used as the internal standard. The sample was deposited by acetonitrile and zinc sulfate then was injected.Results Standard curve was liner in the range of 1.0～50.0 mg/L. The linear equation of vancomycin was Y=0.0873X-0.0061,r=0.9999; the linear equation of norvancomycin was Y=0.1000X-0.0004,r=0.9997. The within-day relative standard deviation (RSD) was less than 4.8%,and between-day RSD less than 6.6%. As for vancomycin,the average method recovery rate of three concentrations were 102.41%,100.44% and 104.69% respectively,and the average extraction recovery rate were 87.54%,89.86% and 88.13% respectively. As for norvancomycin,the average method recovery rate of three concentrations were 99.46%,98.88% and 99.47% respectively,and the average extraction recovery rate were 78.13%,77.41% and 76.45% respectively.Conclusion The operation is simple. The method has stable rate of extraction recovery. It is applicable in concentration determination of vancomycin and norvancomycin in human serum in clinic and other fields." @default.
- W2355223874 created "2016-06-24" @default.
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- W2355223874 date "2009-01-01" @default.
- W2355223874 modified "2023-09-23" @default.
- W2355223874 title "Concentration Determination of Vancomycin and Norvancomycin in Human Serum by HPLC" @default.
- W2355223874 hasPublicationYear "2009" @default.
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