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- W2355243721 abstract "objective To study the effects of exogenous L-arginine on microcirculation and hemorheologies in acute liver injury induced by thioacetamide(TAA).Methods Thirty Wistar rats were dividcd into 4 groups,namely:normal control group(N), L-arginine control group (L-arg), TAA treated group(TAA),L-arg and TAA treated group (L-arg+TAA).The changes of blood viscosity and maximum platelet aggregation (Maxpag) were measured.Meanwhile the liver homogenate levels of NO,MDA,SOD were evaluated by spectrophotometric determination,and thromboxane B2 (TXB2) was detected by radioimmunoassay.Weigert′s staining showed microthrombi.Results The levels of whole blood viscosity,Maxpag and microthrombi in L-arg group significantly decreased (vs other groups, P0.05);whole blood viscosity and Maxpag in L-arg+TAA group also decreased (vs TAA group,P0.05).The levels of hepatic homogenate contents of MDA and TXB2 in L-arg group significantly decreased, but SOD significantly increased (vs L-arg +TAA group).Conclusion Whole blood viscosity,Maxpag,microthrombi,MDA and TXB2 were significantly decreased by treating with exogeneous L-arginine,but SOD significantly increased, and these changes improve hepatic microcirculat-ion." @default.
- W2355243721 created "2016-06-24" @default.
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- W2355243721 date "2004-01-01" @default.
- W2355243721 modified "2023-09-23" @default.
- W2355243721 title "Effects of exogenous L-arginine on microcirculations and hemorheologies in acute liver injury" @default.
- W2355243721 hasPublicationYear "2004" @default.
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