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- W2355248907 abstract "Objectives To investigate the immunohistochemical changes of axons, synapses and dendrites of the spike foci in human epileptic brain. Methods The cortexes of spike foci were surgically obtained from 29 cases with intractable epilepsy. βAPP, synaptophysin and MAP2 immunohistochemistry was used to investigate the changes of axons, synapses and dendrites in the spike foci, respectively. Results The synapses were densely clustered or sparsely scattered. The dendrites were distorted or beaded and lost their branches. The axons did not show visible alterations. In 5 of 10 cases diagnosed as primary epilepsy, neuronal heterotopia was seen in the white matter. Conclusions It was suggested that synaptogenesis, synaptic loss and reorganization may result in abnormal electric activities of epilepsy. The neuronal heterotopia may be one of causes for primary epilepsy." @default.
- W2355248907 created "2016-06-24" @default.
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- W2355248907 date "2004-01-01" @default.
- W2355248907 modified "2023-09-23" @default.
- W2355248907 title "An immunohistochemical study on axons, synapses and dendrites in spike foci of human epileptic brains" @default.
- W2355248907 hasPublicationYear "2004" @default.
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