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- W2355254679 abstract "Objective: To investigate the effects of continuous epidural block combined with pregabalin in the treatment of diabetic peripheral neuropathy.Methods: 36 patients with diabetic peripheral neuropathy were randomly divided into two groups.Group A(n = 18): daily oral pregabalin 300 mg;Group B(n = 18): daily oral pregabalin 300 mg combined with 0.6% lidocaine continuous epidural infusion.Visual analogue scale(VAS),lower extremity pain changes,nerve conduction changes and adverse reactions were recorded in eight weeks.Results: The VAS score in group A began to decline after one week,and then it was obviously lower than before treatment at each time point after therapy(P ﹤ 0.05).But the VAS score in Group B was significantly lower than before treatment at any time point(P ﹤ 0.05).Compared with Group A,the VAS score in B group at each time point was significantly lower than that in group A except the eighth week(P ﹤ 0.05).After 8-week therapy,the electromyography showed motor conduction velocity(MCV) and sensory nerve conduction velocity(SCV) improved significantly in two groups than before therapy(P ﹤ 0.05).Group B was much better than group A(P ﹤ 0.05).There was no significant difference in the incidence of aversive side effects between group A and B(P ﹥ 0.05).Conclusion: Continuous epidural block combined with pregabalin in the treatment of diabetic peripheral neuropathy provides a more rapid onset of pain relief,satisfying analgesia and has lower incidence of adverse effects." @default.
- W2355254679 created "2016-06-24" @default.
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- W2355254679 date "2012-01-01" @default.
- W2355254679 modified "2023-09-25" @default.
- W2355254679 title "CLINICAL STUDY OF EPIDURAL BLOCK COMBINED WITH PREGABALIN IN THE TREATMENT OF DIABETIC PERIPHERAL NEUROPATHY" @default.
- W2355254679 hasPublicationYear "2012" @default.
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