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- W2355257636 abstract "Objective: To explore the relationship between plasma adipose triglyceride lipase (ATGL) and related metabolic indexes of type 2 diabetes mellitus (T2DM) with non-alcoholic fatty liver. Methods: The levels of fasting plasma ATGL were assayed by enzyme-linked immunosorbent assay (ELISA) in 131 patients with incipient T2DM(T2DM group),74 of them without fatty liver (A group),57 of the them with fatty liver(B group) and 44 healthy subjects (NC group). The basal materials and ATGL were compared between three groups. The correlation of ATGL and basal materials were measured as well, and then analyzed by multiple stepwise regression analysis of variables. Results: The level of fasting plasma ATGL was significantly lower in A group than that of NC group [(39.13±23.98) μg/L vs (69.21±27.05) μg/L,P 0.01]. The level of fasting plasma ATGL was significantly lower in B group than that of NC group [(18.25±14.85) μg/L vs (69.21±27.05) μg/L,P 0.01]. The level of fasting plasma ATGL was significantly lower in B group than that of A group (18.25 μg/L±14.85 μg/L vs 39.13 μg/L±23.98 μg/L,P 0.01). The correlation analysis showed that the fasting ATGL level was negatively related with total cholesterol(TC),triglyceride (TG),fasting insulin(Fins),body mass index(BMI) and homeostasis model assessment of insulin resistance(HOMA-IR,r = -0.222,-0.424,-0.317,-0.200 and -0.178,P 0.05). Multiple stepwise regression analysis showed that Fins,BMI and TC were independent related factors that influenced the level of plasma ATGL. Conclusion: ATGL may contribute to the pathogenesis of T2DM with non-alcoholic fatty liver." @default.
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- W2355257636 date "2010-01-01" @default.
- W2355257636 modified "2023-09-23" @default.
- W2355257636 title "An Initial Study of the Relationship between ATGL and Type 2 Diabetes Mellitus with, Non-Alcoholic Fatty Liver" @default.
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