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- W2355266026 abstract "[Objective] To assess the bone healing biology of the tissue engineering bone as a kind of bone graft substitute and its fusion results in a rabbit model of posterolateral lumbar intertransverse process fusion. [Methods] Forty-five New Zealand white rabbits underwent single-level bilateral intertransverse process spine arthrodesis at L5/6. These rabbits were assigned to one of three groups according to the graft materials they received: autogenous iliac crest bone (group A, n=15); tissue engineering bone (group B, n=15); and hydroxyapatite/tricalcium phosphate carrier alone (group C, n=15). Three, three, and nine animals were killed at 2, 6, and 12 weeks after surgery respectively and the spine fusion results were assessed by manual palpation, radiography, histology, and tensile biomechanical testing. [Results] There was no fusion can be seen in all groups at 2 weeks postoperatively. The fusion rate of group A, B, and C at 12th week were 66.67% (8/12), 83.67% (10/12), and 0, respectively. Tensile strength and stiffness of the solidly fused levels in group A and group B were statistically higher than that of group C (P<0.01), but there was no difference between group A and group B (P>0.05). Histological analysis showed that there were some typical chondrocytes in central area of fusion mass in group B. Cartier materials were surrounded by some thin woven bone. The de novo bone in this area was mainly come from the direct osteogenesis. [Conclusion] The tissue engineering bone graft is proved to be a suitable bone graft substitute in the lumbar intertransverse process spine fusion model in rabbit. Its fusion results were same as that of autogenous iliac bone. The residual carrier materials in fusion mass did not interfere with its biomechanical funetian. The healing biology process of this spinal fusion model with tissue engineering bone graft is characterized by its primary direct bone formation in central zone of fusion mass. Membranous bone formation, direct bone formation, and endochondral bone formation can be seen in marginal zone." @default.
- W2355266026 created "2016-06-24" @default.
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- W2355266026 date "2005-01-01" @default.
- W2355266026 modified "2023-09-23" @default.
- W2355266026 title "Posterolateral Lumbar Intertransverse Process Spine Fusion with Tissue Engineering Bone Graft in Rabbit" @default.
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