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- W2355269982 abstract "AIMTo investigate the effects of ovarian hormone on th e expression of 5-HT 3 receptors in the rats colon. METHODS24 adult female SD rats were randomly divided into three groups:sham operation(Sham ) group;ovariectomy(OVX) group and ovariectomy with estrogen and progesterone(OV X+E 2+P) group. The 1 hour fecal pellets and the time of glass pellets output w ere observed 4 weeks after operation;and the expression of 5-HT 3 receptors mR NA in the colon tissues was studied by RT-PCR. RESULTSIn contra st with the Sham group and OVX+E 2+P group,OVX group showed increase in the fec al pellets output and decrease in the time of glass pellets output(P0 01); and the levels of 5-HT 3 receptors mRNA in ovariectomied rats colon tissues w as significantly increased, the expression of 5-HT 3 receptors mRNA was decrea sed in the ovarian hormone replacement therapy(P0 01). CONCLUSION These results indicate that ovarian hormone play a role in regulating 5 -HT 3 receptors in the gastrointestinal tract." @default.
- W2355269982 created "2016-06-24" @default.
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- W2355269982 date "2004-01-01" @default.
- W2355269982 modified "2023-09-25" @default.
- W2355269982 title "Effects of ovarian hormone on 5-HT_3 receptors mRNA expression in the rats colon" @default.
- W2355269982 hasPublicationYear "2004" @default.
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