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- W2355287777 abstract "Objective To explore the effect of celecoxib on the growth of S180 tumor, COX-2 and VEGF-C expression, and lymphangiogenesis in the xenografted mice. Methods Xenografted mice model of S180 cells was established, the growth of tumor, levels of COX-2 and vascular epithelial growth factor(VEGF-C) expression and distribution of lymphatic vessels were studied by macroscopic observation, HE staining, immunochemistry and Western-blot. Results Compared with the control group, the tumor grew slower and the volume of tumor is obviously smaller at the eighth week in Celecoxib-treated group. The expression levels of COX-2 and VEGF-C, the density of lymphtic vessels was decreased in Celecoxib group than in control. Conclusion The inhibition effect of Celecoxib on S180 tumor might be related to the downregulation of COX-2 and VEGF-C expression and lymphangiogenesis." @default.
- W2355287777 created "2016-06-24" @default.
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- W2355287777 date "2010-01-01" @default.
- W2355287777 modified "2023-09-22" @default.
- W2355287777 title "The effect of celecoxib upon the growth of xenografted tumors and lymphangiogenesis in mice" @default.
- W2355287777 hasPublicationYear "2010" @default.
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