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- W2355291249 abstract "Objective Dermal pharmacokinetics of Baijiezi Tufang was studied to provide the reference for explaining the drug mechanism of its asthma prevention and cure.Methods Baijiezi Tufang was applied percutaneously to rats in vivo.Sinapine thiocyanate was used as index and the samples were extracted by microdialysis and detected by reverse phase high performance liquid chromatography(RP-HPLC).The dermal concentration was corrected by relative loss rate,the relationship between concentration and time was analyzed by Kinetica 4.4,and the statistical moment parameters were calculated.The steady absorption rate was calculated too by linear regression of cumulative release to time.Results The time to peak(tmax) of sinapine thiocyanate was 1.5 h,which was the maximum skin concentration appeared at 1.5 h after drug administration.The mean residence time(MRT) was about 22 h and the half time(t1/2) was about 15 h.The steady absorption rate was 13.65 μg/h.Conclusion Dermal pharmacokinetics of Baijiezi Tufang can be studied by microdialysis combined with RP-HPLC.And the dermal pharmacokinetics is in line with the characteristics of Baijiezi Tufang’s prevention and cure for asthma clinically.The combination of microdialysis with RP-HPLC is an appropriate study method." @default.
- W2355291249 created "2016-06-24" @default.
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- W2355291249 date "2012-01-01" @default.
- W2355291249 modified "2023-09-23" @default.
- W2355291249 title "Dermal pharmacokinetic study of Baijiezi Tufang by microdialysis combined with RP-HPLC" @default.
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