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- W2355307142 abstract "Objective To explore the protective effect and mechanism of melatonin (Mel) on rat's hepatic ischemia-reperfusion injury. Methods 72 healthy male Wistar rats (6-7 weeks old ) were randomly divided into 3 groups: Mel treated group (Mel), alcohol solvent control group (Alc) and saline control group (NS). To establish partial hepatic ischemia-reperfusion injury models, malonaldehyde(MDA),superoxide dismutase (SOD)were examined by TBA method and xanthinoxidase method respectively,immunohistochemistry stainning was used to detect the expression of naclear factor (NF-κB). Results The level of MDA in Mel group was significantly lower than that in the Alc and NS groups (P0.05), the level of SOD of Mel group measured in 3h, 12h, 24h after reperfusion was significantly higher than that in Alc and NS groups (P0.05). The expression of NF-κB in Mel group markedly lower than that in Alc and NS groups (P0.05). Without significant differences between Alc and NS group. Conclusion The inhibition of the expression of NF-κB by Mel may be one of the mechanisms for the protective effect of Mel on hepatic ischemia-reperfusion injury ." @default.
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- W2355307142 date "2007-01-01" @default.
- W2355307142 modified "2023-09-25" @default.
- W2355307142 title "Protective Effect of Melatonin on Rat Hepatic Ischemia Reperfusion Injury" @default.
- W2355307142 hasPublicationYear "2007" @default.
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