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- W2355339092 abstract "Objective: To investigate the expression of Bmi-1 and Mel-18 in breast cancer tissue and their clinical significance. Methods: The gene and protein expression in malignant(40 cases),benign(20 cases) and normal(20 cases) breast tissues were determined by RT-PCR and immunohistochemical method,respectively.The Bmi-1 and Mel-18 expression status and their correlationship in breast cancer tissue,and the relations of their expressions with the clinicopathologic factors were analyzed. Results: Both mRNA and protein positive expression of Bmi-1 increased significantly and successively in normal,benign and malignant breast tissues(all P0.05),while those of the Mel-18 showed a roughly opposite tendency(no significant difference between normal breast tissue and benign breast lesion).There was a significant negative correlation between Bmi-1 and Mel-18 expression at either mRNA or protein level in breast cancer tissue(r=–0.317,P=0.023 and r=–0.413,P=0.008).The mRNA and protein levels of both Bmi-1 and Mel-18 were significantly related to the lymph node metastasis and clinical stage(all P0.05),but not associated with the age,menstrual status,tumor size and histologic classification of the patients(all P0.05). Conclusion: The increased Bmi-1 expression along with decreased Mel-18 expression may probably be important biological markers for malignant transformation of breast tissue or invasion and metastasis of breast cancer." @default.
- W2355339092 created "2016-06-24" @default.
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- W2355339092 date "2012-01-01" @default.
- W2355339092 modified "2023-09-25" @default.
- W2355339092 title "Clinicopathological study of Bmi-1 and Mel-18 expression in breast cancer" @default.
- W2355339092 hasPublicationYear "2012" @default.
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