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- W2355354310 abstract "A series of O,O-dialkyl S-carboalkoxyalkyl phosphorodithioates were examined forhydrolysis rates by mouse liver enzyme, anticholinesterase activities to house fly cholines-terase and toxicities to house flies (Musca domestica vicina Macq.) and mice. Linear re-lationships between the logarithm of hydrolysis rate, and also pI_(50), and inductive effectindex (I) of the alkyl radical in the carboalkoxy group were observed. A rough linearrelationship between log LD_(50) (house fly) and pI_(50) was also observed with some devia-tions which are presumably due to the fact that several compounds are more easily ac-tivated in vivo. There is no correlation between mouse liver hydrolysis rate and toxicityto mice, and the evidence indicates that carboxyesterase hydrolysis is not the only factorof the detoxification of these compounds, in which phosphotase hydrolysis may be in-volved. Most of compounds listed in table 3 showed selective toxicity. Among these,AP_4 is the best with a selective ratio (LD_(50) mouse/LD_(50) house fly) of 221." @default.
- W2355354310 created "2016-06-24" @default.
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- W2355354310 date "1965-01-01" @default.
- W2355354310 modified "2023-09-22" @default.
- W2355354310 title "STUDIES ON SELECTIVE ORGANOPHOSPHORUS INSECTICIDES:CHEMICAL STRUCTURE AND BIOLOGICAL ACTIVITY OF ACETHION ANALOGS" @default.
- W2355354310 hasPublicationYear "1965" @default.
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