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- W2355359891 abstract "Aim To study the relationships between carotid plaque and plasma matrix metalloproteinase and tissue inhibitor metalloproteinase in patients with acute coronary syndrome(ACS). Methods Using high-resolution ultrasonic instrument the intima-media thickness(IMT)and plaque score in carotid artery were detected in 30 patients with ACS,29 patients with stable angina pectoris(SAP)and 17 control subjects,and the plasma concentration of matrix metalloproteinase9(MMP-9)and tissue inhibitor metalloproteinase-1(TIMP-1)were measured by sandwich enzyme immunoassay technique. Results Compared with SAP group and control group,plasma MMP-9,TIMP-1,MMP-9/TIMP-1,and IMT,whole plaque score,soft plaque score and hard plaque score in carotid artery in ACS group were significantly increased(P0.01).MMP-9 had positive relationship with IMT,whole plaque score and soft plaque score in carotid artery(r=0.468,P0.01;r=0.592,P0.01;r=0.677,P0.01),respectively.TIMP-1 had positive relationship with IMT,whole plaque score,soft plaque score and hard plaque score in carotid artery(r=0.449,P0.01;r=0.493,P0.01;r=0.435,P0.01;r=0.227,P0.05),respectively.MMP-9/TIMP-1 had positive relationship with IMT,whole plaque score and soft plaque score in carotid artery(r=(0.253),P0.05;r=0.431,P0.01;r=0.547,P0.01), respectively.Removing age factor,partial correlation analysis showed IMT had positive relationship with MMP-9(r=0.461,P0.001),TIMP-1(r=0.441,P0.001),MMP-9/TIMP-1(r=0.241,P0.01),respectively. Conclusions Plasma MMP-9,TIMP-1,MMP-9/TIMP-1,and IMT,whole plaque score,soft plaque score and hard plaque score in carotid artery in ACS group are significantly higher than those in SAP group and control group.Plasma MMP-9,TIMP-1,MMP-9/TIMP-1 have positive relationship with IMT,whole plaque score and soft plaque score in carotid artery,respectively." @default.
- W2355359891 created "2016-06-24" @default.
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- W2355359891 date "2005-01-01" @default.
- W2355359891 modified "2023-09-24" @default.
- W2355359891 title "The Relationships Between Carotid Plaque and Plasma Matrix Metalloproteinase in Patients with Acute Coronary Syndrome" @default.
- W2355359891 hasPublicationYear "2005" @default.
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