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- W2355360006 abstract "Objective To investigate the effects of contextual familiarity on behavioral sensitization induced by chronic morphine administration in mice. Methods (1) Experiment 1: Mice were administrated subcutaneously morphine(10 mg/kg,once per day) for consecutive 7 days either in the test chamber(novel context) or home cage(familiar context).After a 6-day washout period,the mice were challenged with 10 mg/kg morphine and then put into the test chambers to measure their locomotor activity for 1 h.(2) Experiment 2: Mice were administrated subcutaneously morphine(10 mg/kg,once per day) for consecutive 7 days.After a 6-day washout period,the mice were challenged with 10 mg/kg morphine and then put into the test chambers to measure their locomotor activity for 1 h.The paired groups were measured for their locomotor activity in the context in which morphine or saline was administrated,however,the unpaired groups were measured for their locomotor activity in the context in which no morphine or saline was administrated.Results (1) Experiment 1: Pairing morphine administration to the novel context,not the familiar context,induced behavioral sensitization in mice.(2) Experiment 2: The expression of behavioral sensitization was only observed in the context in which morphine was administrated. Conclusion The induction of morphine behavioral sensitization in mice is related to the contextual familiarity,and this expression of behavioral sensitization is context-dependent." @default.
- W2355360006 created "2016-06-24" @default.
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- W2355360006 date "2007-01-01" @default.
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- W2355360006 title "Effects of Contextual Familiarity on Behavioral Sensitization Induced by Chronic Morphine Administration in Mice" @default.
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