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- W2355363620 abstract "Objective To observe the expression and the role of hypoxic inducible factor(HIF)-1α induced by inflammatory factor and infection factor in primary human nasal epithelial cell(HNEC).Methods Epithelial cells of nasal polyps(NP) and inferior turbinate(IT) were cultured without serum under stimulus of LPS 10,100,1 000 ng/ml and IL-1β 20 ng/ml for 3,6,9 h respectively.The expression of HIF-1α protein and mRNA derived from epithelial cells was detected by immunocytochemistry and in situ hybridization.Results ① The expression of HIF-1α increased under the stimulus of inflammatory factor with the increasing of time and concentration,especially by LPS 100 ng/ml at 6 hour(P0.05);②The expression tendency of HIF-1α induced by IL-1β was the same as that by LPS groups,and the expression intensity of HIF-1α induced by IL-1β was lower than that by LPS 100 ng/ml,but there was no differences between them.③The HIF-1α expressed more intensively in epithelial cells from NP than IT under all conditions(P0.05);Conclusions Epithelial cells actively produce vast HIF-1α under inflammatory factor and infection factor to induce overexpressed correlated factors,which is one of important factors of formation of NP." @default.
- W2355363620 created "2016-06-24" @default.
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- W2355363620 date "2008-01-01" @default.
- W2355363620 modified "2023-09-28" @default.
- W2355363620 title "Expression and the role of HIF-1α in human nasal epithelium mucosae cells" @default.
- W2355363620 hasPublicationYear "2008" @default.
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