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- W2355365625 abstract "OBJECTIVE To study the effect of the genetic factors on the occurrence and development of Alzheimer Disease (AD) and its general genetic pattern. METHODS 29 AD cases, as probands, were investigated for AD genealogical tree.The heritability of AD was estimated by Falconer method.AD genetic pattern were evaluated with Penrose’s method, the threshold value model method of Jiang San-duo. RESULTS The prevalent rate of AD in first-degree relatives was 5.06% , which was higher than that in general population.The heritability of AD was 53.34% . The s/q score was 6.348 with Penrose’s method, which was near to 1/q1/2 . The theoretical prevalent rate in first relatives was 5.10% , while the investigated prevalent rate was 5.06% . CONCLUSION There is an obvious heritable trend in AD.It is fit to the multi-factorial inheritance pattern but the mono-gene heritability model." @default.
- W2355365625 created "2016-06-24" @default.
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- W2355365625 date "2013-01-01" @default.
- W2355365625 modified "2023-09-23" @default.
- W2355365625 title "Genetic epidemiological study on Alzheimer disease" @default.
- W2355365625 hasPublicationYear "2013" @default.
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