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- W2355367054 abstract "Objective:To find out genes that are responsibe for the protection of astrocyte against the neurotoxicity of rotenone.Methods:To address this question,MN9D cells was used as a cell model of dopaminergic neurons and rotenone a toxin to initiate mitochondrial deficiency and wonder whether ACM could protect MN9D cells against rotenone toxicity and its possible protective mechanism.Cells treated with ACM or not were exposed to rotenone before assay of cell viability,signal transduction pathway for apoptosis and so on.Results:The results showed that rotenone decreased viability of MN9D cells in a dose-dependent manner and ACM treatment significantly attenuated rotenone toxicity at each concentration.Results of genechip found 104 differentially expressed genes,among which there were 62 up-regulated genes and 42 down-regulated ones after ACM treatment.These genes involved many functions such as signal transduction,transcription regulation,metabolism,cell cycle,etc.According to previous literature and the present study,3 genes,namely Nrf3,GCL and NQO1 were likely to be associated with ACM protection and were confirmed by real-time PCR.Conclusions:The findings suggest that astrocytes can protect MN9D cells from oxidative stress and mitochondrial dysfunction caused by rotenone.Glutathione and neurotrophic factors may partially account for the protection.Some meaningful genes related to ACM protection were selected by genechip.Further research into these genes may provide clues to the detailed mechanism of ACM protection and shed light on accurate role of astrocytes in Parkinson's disease." @default.
- W2355367054 created "2016-06-24" @default.
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- W2355367054 date "2010-01-01" @default.
- W2355367054 modified "2023-09-23" @default.
- W2355367054 title "Nrf3 Pathway was Involved in the Protection of Astrocyte Against the Neurotoxicity of Rotenone" @default.
- W2355367054 hasPublicationYear "2010" @default.
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