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- W2355368101 abstract "Objective To observe the expression of the new co-stimulatory molecule B7-H1 in mouse microglial cells and its changes after LPS activation,for investigating the immune function of microglial cells in the CNS inflammation.Methods The microglial cell line N9 was stimulated with LPS,and then the expression of B7-H1 was detected by RT-PCR,real-time RT-PCR,flow cytometry,and immunohis-(chemistry.) After isolation and cultivation,the primary microglial cells was identify by GSA-IB4 staining and the B7-H1 expression change after LPS stimulation was found by using immunohischemistry.Results ①Resting N9 could express B7-H1 and the LPS stimulation could up-regulate the expression as well as accumulate the production of TNF-α and NO.② The isolated primary microglia cells,whose purity was more than 95% by GSA-IB4 staining,were constitutively expressed B7-H1 which up-regulated significantly after LPS stimulation.Conclusion The N9 and primary microglial cells could constitutively express co-stimulatory molecule B7-H1 and the expression can be increased significantly by LPS stimulation,which maybe play an important role in modulating the CNS immune response." @default.
- W2355368101 created "2016-06-24" @default.
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- W2355368101 date "2006-01-01" @default.
- W2355368101 modified "2023-09-23" @default.
- W2355368101 title "Microglial expression of B7-H1 and its change after LPS stimulation" @default.
- W2355368101 hasPublicationYear "2006" @default.
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