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- W2355380010 abstract "Objective To investigate the effect of metformin on serum insulin,sex hormones and sex hormone-binding globulin(SHBG)level,and to explore the mechanisms in polycystic ovary syndrome(PCOS) with hyperinsulinemia.Methods Twenty-four PCOS women with hyperinsulinemia participated in the study and were administered with metformin at a dose of 500 mg three times a day for 8 weeks.Serum insulin and sex hormones were detected before and then after a 8 week metformin therapy.Results Metformin induced a significant decrease in serum insulin and testosterone levels(P0.01).It also led to an increase in insulin sensitivity index(P0.01).No significant difference in serum SHBG were observed after metformin therapy(P0.05).Conclusion Metformin can decrease serum insulin and testosterone levels,improve the micro-environment of ovary,thus metformin is an important therapy for PCOS." @default.
- W2355380010 created "2016-06-24" @default.
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- W2355380010 date "2010-01-01" @default.
- W2355380010 modified "2023-09-23" @default.
- W2355380010 title "Effect of Metformin on Serum Insulin and Sex Hormone in PCOS with Hyperinsulinemia" @default.
- W2355380010 hasPublicationYear "2010" @default.
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