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- W2355387625 abstract "Objective:To investigate the relationship between p21WAF1 gene expression and histone acetylation in gastric cancer. Methods:p21WAF1 gene expression of cancer tissue, para-focus of cancer and normal tissue in 53 cases with primary gastric cancer were analyzed with RT-PCR, meanwhile, histone acetylation in 7 cases with p21WAF1 mRNA non-expression or expression less than half of para-focus of cancer and normal tissue were analyzed with Western blot hybridization. Results:① Both p21WAF1 expression ratio and value of gastric cancer were lower than those of para-focus of cancer and normal tissue. ② p21WAF1 expression level had no difference between well-differentiated and poorly-differen- tiated gastric cancer (P0.05), but there was significantly difference in different invasion depth and had none lymph node metastasis (P0.05, P0.01). ③ The expression of acetylated histone-H3 in total chromatin of 5 cases (5/7, 71.43%) was significantly lower than those of para-focus of cancer and normal tissue corresponding to them, even under detective level. Conclusion:The lower expression of p21WAF1 in gastric cancer is partly due to lower level of histone acetylation." @default.
- W2355387625 created "2016-06-24" @default.
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- W2355387625 date "2008-01-01" @default.
- W2355387625 modified "2023-09-27" @default.
- W2355387625 title "Preliminary study on the relationship of p21~(WAF1) gene expression in gastric cancer and histone acetylation" @default.
- W2355387625 hasPublicationYear "2008" @default.
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