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- W2355398125 abstract "OBJECTIVE:To identify the role of the hepatic CYP isoenzymes involved in paclitaxel biotransformation and to evaluate the metabolic drug interaction between paclitaxel and other anticancer agents.METHODS:The female wistar rats were pretreated with saline,dexamethasone or ketoconazole respectively before paclitaxel,and their levels of CYP3A were determined.Then 135 rats received paclitaxel at dose level of 10 mg·kg -1 (iv).Nine plasma samples were obtained up to 12 hours after injection.Paclitaxel were quantified by HPLC.Their pharmacokinetics were assessed by noncompartment model and model dependent method,respectively.RESULTS:It was found that the c max value of 68.91,56.51 and 108.53 μg·ml -1 were obtained in controlled,induced and inhibited group,respectively.The Cl values (0.0242,0.037 and 0.0105 L·h -1 ,respectively)were reached.CONCLUSION:It suggested that liver cytochrome P450 3A subfamily plays a major role in paclitaxel biotransformation.These finding may have clinical implications and should be taken into account in chemotherapy." @default.
- W2355398125 created "2016-06-24" @default.
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- W2355398125 date "2000-01-01" @default.
- W2355398125 modified "2023-09-23" @default.
- W2355398125 title "Effects of CYP3A on pharmacokinetics of paclitaxel in rats" @default.
- W2355398125 hasPublicationYear "2000" @default.
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