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- W2355402021 abstract "Objective To study the effects and significance of heat shock response (HSR) on heat stroke (HS).Method SD male rats were randomly divided into three groups,i.e., HS group,HS control group(HSC)and normal control group(NC).Rats in HS group were pretreated by heat and those in the HSC group were not.Twenty hours later,the rats in HS group were placed in a heat cabin for 73 minutes to cause them HS and blood pressure and electrocardiograph were monitored for them during they stayed in the heat cabin.Serum levels of malonyl dialdehyde (MDA) and nitric oxide(NO) were measured for the rats after heat exposure.No treatment for the rats in NC groups was given.Their mean arterial pressure (MAP),systolic pressure (SP),diastolic pressure(DP),heart rate (HR) were obtained for all the rats by Chart software.Result (1) MAP,SP and DP in HS and HSC groups were significantly lower than those in NC,P0.01,and HR was higher in HS and HSC than that in NC,P0.01.MAP,SP,DP and HR in HS group were significantly higher than those in HSC,P0.01 and P0.05,respectively.(2)Serum levels of MDA and NO were significantly higher in HSC than those in NC,P0.05 and P0.01,respectively,at 73 minutes after heat exposure,and serum levels of MDA was significantly lower in HS group than those in HSC one,P0.05,but not significantly differing from those in NC one.Content of NO in HS group was also lower than in HSC group(P0.01).Conclusion HSR could reduce occurrence of heat stroke in rats,possibly by inhibiting over synthesis of MDA and NO." @default.
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- W2355402021 date "2004-01-01" @default.
- W2355402021 modified "2023-09-23" @default.
- W2355402021 title "Effects and significance of heat shock response on heat stroke in rats" @default.
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