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- W2355416043 abstract "Objective:To study the changes of Caspase 8 and Caspase 3 activity in TRAIL-induced apoptosis of neuroblastoma cell line CHP212 cells.Methods:The effects of TRAIL and Caspase 8/Caspase 3 inhibitor+ TRAIL on the apoptosis of CHP212 cells was detected by flow cytometry.The relative Caspase 8 /Caspase 3 activity was measured by colorimetric assay.The morphous of the apoptosis cells was detected by using the transmission electron microscope(TEM).Results:TRAIL could induce apoptosis of CHP212 cells with dose dependency.Caspase 8/Caspase 3 inhibitor could diminish the apoptosis of CHP212 cells induced by TRAIL.The relative Caspase 8/Caspase 3 activity of CHP212 cells increased gradually with the prolongation of TRAIL action time and reached the peak at 16h and 8h respectively.Typical features of apoptosis were seen by TEM.Conclusion:TRAIL could induce apoptosis of CHP212 cells through Caspase-transduced signal pathway with the increase of Caspase8 and Caspase 3 activity." @default.
- W2355416043 created "2016-06-24" @default.
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- W2355416043 date "2008-01-01" @default.
- W2355416043 modified "2023-09-26" @default.
- W2355416043 title "Changes of Caspase 8 and Caspase 3 activity in TRAIL-induced apoptosis of CHP212 cells" @default.
- W2355416043 hasPublicationYear "2008" @default.
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