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- W2355418560 abstract "Objective To investigate the time course of emergence and resolution of neovascularization(NV) in oxygen-induced retinopathy(OIR) and the associated changes of cyclin D1 protein in OIR.Methods About 120 SD rats with 7 days old were randomly divided into experimental group and control group.There were 60 rats in experimental group with exposion in 75% hyperxia environment for 5 days for inducing retinopathy models.Additional 60 rats were raised in room air as age matched controls.Twelve rats were selected at the postnatal 12th day,14th day,17th day,22th day and 26th day and both eyeballs were taken out.The rat's left eyes were removed for neovascularization analysis,immunohistochemistry and immunofluorescence staining of cyclin D1.The retina of right eyes in all rats had been performed Western blot analysis of cyclin D1 protein.Results In OIR,NV started to emerge at the 14th day,went to maximal at the 17th day,and then gradually degenerated.NV strucutre went to normal at the 26th day.Immunohistochemical staining and immunofluorescence revealed the high expression of cyclin D1 at the 14th day,17th day,22th day in experimental group.Western blotting method further demonstrated that the expression of cyclin D1 in experimental group decreased at the 12th day,increased at the 14th day,went to peak at the 17th day,and decreased at the 26th day,but still higher than that in control group.The expression of cyclin D1 was consistent with the proliferation of NV.Conclusion The abnormal expression of cyclin D1 has close relation with proliferation of retinal NV." @default.
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- W2355418560 date "2011-01-01" @default.
- W2355418560 modified "2023-09-24" @default.
- W2355418560 title "Expression of cyclin D1 in rat models of oxygen-induced retinopathy" @default.
- W2355418560 hasPublicationYear "2011" @default.
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