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- W2355421330 abstract "Objective To explore the co-operative effect of angiopoietin-1(Ang1) and vascular endothelail growth factor(VEGF165) in angiogenic response in rabbit model of acute hindlimb ischemia.Methods Creat rabbit model with acute hindlimb ischemia in 53 rabbits by ligation of the external iliac artery and the excision of the common and superficial femoral artery,250ug of phVEGF165(n=14),500 ug of phAng1(n=14),250 ug of phVEGF165 plus 500 ug of phAng1(n=14) and PBS(control group,n=11) was injected intramuscularly into the ischemic hindlimb muscles.The transfected muscles were harvested 3,7,14,30days later,detecting the expression of VEGF165 or Ang1 and investigating capillary density stained by Ⅷ.Gross appearance of ischemic limb,collateral vessel formation and limb perfusion were assessed 30 days after treatment.Results The incidence of ischemic limb necrosis was higher in the animals treated by VEGF165,by Ang1 or by PBS than that in those treated by VEGF165 plus Ang1(18.2%,45.5%,27.3% and 100%,respectively).Animals in four group had no significance in maximum calf blood velocity at day 30(P 0.05).A combination therapy of VEGF plus Ang1 had a significantly higher(q=61.2034,q=54.6494,q=50.0568,P0.01) angiographic score than either therapy alone or control group.Capillary density(q=227.7980,q=144.0765,q=100.2765,P0.01) in the combination therapeutic group was also significantly higher than that of either therapy alone or control group.Conclusion Ang1 can potentiate the angiogenic response to VEGF in rabbit model of acute hindlimb ischemia.Intramuscular administration of cytokines on revascularization of the ischemic hindlimb model of rabbit is feasible." @default.
- W2355421330 created "2016-06-24" @default.
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- W2355421330 date "2007-01-01" @default.
- W2355421330 modified "2023-09-25" @default.
- W2355421330 title "Cooperative Effect of Angiopoietin-1 and Vascular Endothelial Growth Factor inNeoangiogenesis in Rabbit Model with Acute Hindlimb Ischemia" @default.
- W2355421330 hasPublicationYear "2007" @default.
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