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- W2355423663 abstract "Objective To observe the effect chemotherapy on the immune function of patients with gastrointestinal malignant tumor in the later stage.Methods The changes of Th1(IL-2)and Th2(IL-2)cytokines in peripheral blood of the patients before and after chemotherapy were determined.Results Before ehmocherapy the level of IL-2 in patients with gastrointestinal malignant tumor was significantly lower than that of normal group(P0.05)and the the concentration of IL-10 was increased in tumor patients than that of normal controls(P0.05).After chemotherapy of two courses,the level of IL-10 in the improved patients of observation group was lower significantly than that of before chemotherapy(CR+PR),but the concentration could not reach the level of the normal group.The level of IL-10 decreased significantly in patients without improvement of the observation(SD+PD)without showing significant difference compared with that before chemotherapy.Conclusion The immune function of T-lymphocyte subgroup is suppressed in the patients with gastrointestinal malignant tumor and the expression of Th2 type cytokines is enhanced.The tumor cells can be keilled by chemotherapy.The determination of Th1/Th2 cellular cytokines can ascertain the immune function of the patients and the the effect of chemotherapy that are useful for prognosis of the disease." @default.
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- W2355423663 date "2007-01-01" @default.
- W2355423663 modified "2023-09-24" @default.
- W2355423663 title "Impact of chemotherapy on imune function of patients with gastrointestinal malignant tumor at advanced stage" @default.
- W2355423663 hasPublicationYear "2007" @default.
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