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- W2355433959 abstract "Objective To investigate the effect of rosuvastatin on hyper-LDL cholesterolemia in schizophrenic patients.Methods 64 schizophrenics with hyper-LDL cholesterolemia were randomly divided into study group( n = 31) treated with antipsychotics plus rosuvastatin and control group( n = 33) treated with antipsychotics for 8 weeks. All patients were assessed with Positive and Negative Syndrome Scale( PANSS) and Treatment Emergent Symptom Scale( TESS) at baseline and at the end of the 4th,8th week of the treatment to evaluate the efficacy and side effects. Metabolic indexes including level of LDLcholesterol( LDL-C),fasting blood sugar,waist circumference and body mass were measured at the baseline and at the end of the 2nd,4th,6th,8th week. Results Compared with the baseline,negative factor score of PANSS in study group decreased significantly( P 0. 05),body mass,waist circumference and level of LDL-C in study group decreased significantly( P 0. 05). Level of LDL-C in study group was significantly lower than that in control group at the end of the 6th,8th week of the treatment( P 0. 05 and P 0. 01,respectively). Body mass and waist circumference in study group were significantly lower than those in control group at the end of the 8-week treatment( P 0. 01). Conclusion Rosuvastatin can effectively improve metabolic indexes in schizophrenic patients with hyper-LDL cholesterolemia." @default.
- W2355433959 created "2016-06-24" @default.
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- W2355433959 date "2014-01-01" @default.
- W2355433959 modified "2023-09-23" @default.
- W2355433959 title "The effect of rosuvastatin on hyper-LDL cholesterolemia in patients with schizophrenia" @default.
- W2355433959 hasPublicationYear "2014" @default.
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