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- W2355447510 abstract "Object: To investigate the effect of Radix Astragali injection on oxidative stress from rat with chronic pancreatic fibrosis,and to explore the mechanism of alleviation pancreatic fibrosis.Method: Rats were randonmly divided into six groups.The injection method of 2% TNBS through rat's pancreatic duct was undertaken to set up the animal model of pancreatitis.The rats which included in low dose group,moderate dose group and high dose group were treated by Radix Astragali injection.At the end of 6th week,all the survived rats were sacrificed.The expressions ofα-SMA and collagenⅠwere detected by the method of immunohistochemistry.The content of MDA and the activity of GSH-PX in serum were detected by the method of ELISA.Result: Both the content of MDA in serum and the content of α-SMA and collagenⅠsecreted by pancreas was dropped respectively by Radix Astragali injection except that activity of GSH-PX showed opposite trend.All effects showed a dose-dependence,comparing with the control group,with significant differences(P0.05).Conclution: Radix Astragali injection can decrease the effect of oxidative stress of CP and inhibit activation of PSC,resulting in alleviating the fibrosis of the pancreas." @default.
- W2355447510 created "2016-06-24" @default.
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- W2355447510 date "2011-01-01" @default.
- W2355447510 modified "2023-09-28" @default.
- W2355447510 title "The Effect of Radix Astragali Injection on Oxidative Stress From Rat with Chronic Pancreatic Fibrosi" @default.
- W2355447510 hasPublicationYear "2011" @default.
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