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- W2355463044 abstract "Objective To observe the effect of Acanthopanax senticosus saponins (ASS) on total cholesterol (TC), lipoprotein cholesterol metabolism and antioxidative activity in experimental hyperlipidemia rats. Methods The TC, lipoprotein cholesterol and lipid peroxidation (LPO) contents, prostacycline (PGI 2) and thromboxane (TXA 2) levels, superoxide dismutase (SOD) activity and blood viscosity were measured respectively in hyperlipidemia rats which had been given ASS 25, 50 and 100 mg·kg -1 ·d -1 ip, respectively, for twenty one days. In addition, fat accumulation in liver was observed. Results The triglyceride (TG), TC, low density lipoprotein cholesterol (LDL c) in serum, TXA 2 in plasma, LPO in serum and liver and blood viscosity were decreased significantly, and high density lipoprotein cholesterol (HDL c) in serum, PGI 2 in plasma and SOD in serum and liver were significantly increased by given ASS (50 and 100 mg·kg -1 ·d -1 ) in experimental hyperlipidemia rats. Moreover, ASS could decrease ratioes of TC/HDL c, LDL c/HDL c, increase the ratio of PGI 2/TXA 2 and inhibit fat accumulation in liver. Conclusion ASS can inhibit arteriosclerosis by improving cholesterol and lipoprotein cholesterol metabolism, suppressing LPO,and increasing the activity of antioxidase." @default.
- W2355463044 created "2016-06-24" @default.
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- W2355463044 date "2004-01-01" @default.
- W2355463044 modified "2023-09-25" @default.
- W2355463044 title "Effects of Acanthopanax senticosus saponins on blood lipid metabolism and antioxidative activity in experimental hyperlipidemia rats" @default.
- W2355463044 hasPublicationYear "2004" @default.
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