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- W2355463811 abstract "Objective:The purpose of the present study mainly aimed to investigate the degree of systemic inflammation reflected by circulatory levels of C reactive protein(CRP),interleukin(IL)-6,tumor-necrosis factor(TNF)-α,and B-type brain natriuretic peptide(BNP)in COPD patients with and without pulmonary hypertension.Methods:A total of 80 COPD patients [32 females and 48 males;age,(74±9) years;mean FEV1%,(59.4%±29.4%) predicted] admitted to the department of respiratory medicine and the emergency intensive care unit of Beijing Anzhen Hospital were consecutively recruited from September of 2011 to July of 2012;pulmonary artery pressure(Ppa) levels were measured by echocardiography;serum CRP level was assessed by particle enhanced transmission immunoturbidimetry assay,serum IL-6、TNF-αwere measured by enzyme-linked immunosorbent assay,plasma BNP was measured by chemiluminescence microparticle immuno assay.Results:COPD with pulmonary hypertension group(A group) and COPD without pulmonary hypertension group(B group) were all have forty patients.In A group,CRP、IL-6、 TNF-αand BNP levels were significantly higher than in B group[median 6.5(2.7~21.1) vs.1.9(0.6~5.2)mg/L];[median 106.6(41.0-368.6) vs.73.9(12.0-152.1) ng/L];[mean(19.4±10.2) vs.(14.9±5.3)ng/L];[median 137.0(92.2-299.6) vs.45.1(20.4-98.5)ng/L].A significant linear relationship was observed between log-transformed CRP or log-transformed BNP level and systolic Ppa in whole group.In Logistic regression analysis,CRP and BNP were independent predictors of systolic Ppa.Conclusion: We conclude that increases in Ppa in patients with COPD are associated with higher levels of CRP、IL-6、TNF-α and BNP.It suggests that inflammation might be one of the key mechanisms involved in COPD with pulmonary hypertension patients." @default.
- W2355463811 created "2016-06-24" @default.
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- W2355463811 date "2013-01-01" @default.
- W2355463811 modified "2023-09-24" @default.
- W2355463811 title "Study on the relationship between pulmonary hypertension in patients with chronic obstructive pulmonary disease and inflammatory reaction" @default.
- W2355463811 hasPublicationYear "2013" @default.
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