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- W2355464324 abstract "Objective Exploring the role of advanced glycosylation end products in the pathogenesis of ovariectomy-induced osteoporosis and prevention and treatment for ovariectomy-induced osteoporosis with aminoguanidine. Methods 10 months rats were ovariectomized to induce osteoporosis in this study.Determining bone mineral density, contents of AGEs from bone collagen,biochemical indexes in serum and urine which related to bone metabolism.Results Contents of AGE from ovariectomized rats' bone collagen (59.86RU/mg collagen±3.13 RU/mg collagen) were higher than that from sham group(53.83 RU/mg collagen ±5.46 RU/mg collagen) (P0.01).Bone mineral density(0.207g/crn2±0. 010 g/crn2) were significantly reduced in the ovariectomized rats compared with that in sham group (0.236 g/ crn2±0.017 g/ crn2) (P0.01).Levels of Serum estrogen (4.50pg/ml±1.73pg/ml) in ovariectomized rats had a decrease compared with that in sham group (8.45pg/ml±2.90pg/ml ) (P0.02). Levels of Ca/Cr, contents of Ca, Levels of P/Cr, contents of P in ovariectomized rats' urine have an increased tendency. Tibia bone mineral density (0.221 g/ crn2±0.017 g/ crn2) from the ovariectomized rats given with aminoguanidine was higher compared with that in ovariectomized rats (P0.05). Contents of AGEs(51.23 RU/mg collagen±7.46 RU/mg collagen) from bone collagen in ovariectomized rats given with aminoguanidine were lower than that from ovariectomized rats (P0.01). Levels of Serum estrogen (8.59pg/ml±3.01pg/ml ) in ovariectomized rats given with aminoguanidine had an increase compared with that in ovariectomized rats (P0.01). Levels of Ca/Cr, contents of Ca, contents of HOP from urine in ovariectomized rats given with aminoguanidine remarkably decreased compared with that in ovariectomized rats.Conclusions Increased AGEs contents from bone collagen in ovariectomized rats and decreased serum estrogen levels resulted in the reduced bone formation absolutely and the increased bone resorption relatively by multiplex ways. Which was responsible for the pathogenesis of postmenopausal osteoporosis and Aminoguanidine can prevent ovariectomized rat from bone loss by repressing the AGE production." @default.
- W2355464324 created "2016-06-24" @default.
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- W2355464324 date "2003-01-01" @default.
- W2355464324 modified "2023-09-25" @default.
- W2355464324 title "The role of AGEs in the pathogenesis of ovariectomy-induced osteoporosis and prevention and treatment with aminoguanidine" @default.
- W2355464324 hasPublicationYear "2003" @default.
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